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Table 3 The baseline characteristics of survivors and non-survivors

From: Serum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis

FOP patients

≤18y

>18y

Total

survivors

(group A)

non-survivors (group B)

survivors

(group C)

non-survivors (group D)

Cases

40(88.9%)

5(11.1%)

16(80%)

4(20%)

65

Gender ratio (M/F)

21/19

1/4

6/10

2/2

30/35

Age at diagnose (years)

9.6 ± 5.0

11.6 ± 6.3

24.4 ± 7.1 **

25.5 ± 2.4 **

14.4 ± 8.8

Age of onset

3.6 ± 2.9

2.3 ± 2.3

4.6 ± 4.4

3.4 ± 2.2

4.2 ± 3.9

Age at death (years)

17.4 ± 7.2

29.5 ± 2.9

22.8 ± 8.9

OC (ng/mL)

87.7 ± 32.7

48.7 ± 15.5**

34.7 ± 19.8**

26.8 ± 16.1**

67.9 ± 37.8

Ca (mmol/L)

2.32 ± 0.2

2.34 ± 0.07

2.32 ± 0.08

2.24 ± 0.05

2.32 ± 0.15

P (mmol/L)

1.58 ± 0.25

1.42 ± 0.15

1.23 ± 0.3**

1.02 ± 0.21**

1.45 ± 0.31

PTH (pg/mL)

63.3 ± 487.4

53.2 ± 25.9

81.5 ± 37.7

71.9 ± 14.3

67.5 ± 42.8

ALP (IU/L)

244.0 ± 121.1

128.2 ± 85.0*

121.9 ± 78.6**

82.2 ± 24.9*

192.3 ± 121.9

ESR (mm/hr)

7.9 ± 5.2

9.4 ± 8.7

10.2 ± 9.2

9.25 ± 5.6

8.6 ± 7.8

ALT (U/L)

14.9 ± 7.2

10.6 ± 3.4

15.0 ± 10.6

16.7 ± 13.2

14.6 ± 8.0

AST (U/L)

24.6 ± 9.7

23.1 ± 6.0

25.3 ± 10.9

19.57 ± 12.7

24.3 ± 13.3

Cr (umol/L)

38.0 ± 14.3

31.0 ± 5.2

46.8 ± 14.0

43.7 ± 11.3

39.4 ± 14.0

BUN (mmol/L)

2.0–5.8

1.7–7.2

2.9–6.3

2.2–5.3

1.7–7.2

  1. Compared with group A, *P < 0.05, **P < 0.01; Compared with group B, P < 0.05, P < 0.01;
  2. OC osteocalcin, Ca total serum calcium, P phosphorus, PTH parathyroid hormone, ALP alkaline phosphatase, ESR erythrocyte sedimentation rate, CRP C-reactive protein, ALT alanine aminotransferase, AST aspartate aminotransferase, Cr creatinine, BUN blood urea nitrogen