Variable | single-dose | two-dose | multiple-dose | P value | Intergroup comparison | ||
---|---|---|---|---|---|---|---|
P1 P2 P3 | |||||||
Primary outcomes | |||||||
TBL(mL) | 1138 ± 404 | 978 ± 311 | 727 ± 278 | 0.002a | 0.192 | 0.001 | 0.015 |
HBL(mL) | 581 ± 216 | 493 ± 165 | 416 ± 141 | < 0.001a | 0.179 | 0.010 | 0.142 |
Transfusion rate (n,%) | 3(16.7%) | 1(5.6%) | 1(5.6%) | 0.414b | – | – | – |
Secondary outcomes | |||||||
Duration of surgery (min) | 137.23 ± 16.34 | 139.41 ± 17.55 | 125.83 ± 20.15 | 0.063a | – | – | – |
Hospitalization days (d) | 7.74 ± 1.20 | 7.95 ± 1.35 | 7.45 ± 1.00 | 0.456a | – | – | – |
Drainage volume (mL) | 446 ± 218 | 322 ± 185 | 274 ± 118 | 0.017a | 0.074 | 0.006 | 0.360 |
Maximum Hb drop(g/L) | 20.22 ± 12.31 | 19.84 ± 10.77 | 17.84 ± 10.77 | 0.795a | – | – | – |
Postop. Laboratory values | |||||||
Hb (g/L) | |||||||
POD#1 | 113.17 ± 10.14 | 113.93 ± 9.74 | 115.15 ± 10.22 | 0.837a | – | – | – |
POD#3 | 104.16 ± 12.33 | 106.71 ± 11.51 | 113.64 ± 10.18 | 0.043a | 0.526 | 0.017 | 0.064 |
Hct (%) | |||||||
POD#1 | 34.46 ± 3.77 | 34.51 ± 2.35 | 36.14 ± 3.26 | 0.207a | – | – | – |
POD#3 | 31.07 ± 5.13 | 31.37 ± 3.43 | 33.52 ± 2.87 | 0.135a | – | – | – |
D-dimer (mg/L) | |||||||
POD#1 | 3.96 ± 1.14 | 4.01 ± 1.59 | 3.74 ± 1.33 | 0.820a | – | – | – |
POD#3 | 2.62 ± 0.81 | 2.88 ± 0.72 | 2.33 ± 0.60 | 0.116a | – | – | – |
FDP (mg/L) | |||||||
POD#1 | 7.67 ± 1.21 | 7.51 ± 1.39 | 6.84 ± 0.93 | 0.096a | – | – | – |
POD#3 | 4.84 ± 1.16 | 4.64 ± 1.03 | 4.68 ± 0.87 | 0.827 a | – | – | – |