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Table 2 Comparison of the primary and secondary outcomes of the three groups

From: Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?

Variable

single-dose

two-dose

multiple-dose

P value

Intergroup comparison

P1 P2 P3

Primary outcomes

 TBL(mL)

1138 ± 404

978 ± 311

727 ± 278

0.002a

0.192

0.001

0.015

 HBL(mL)

581 ± 216

493 ± 165

416 ± 141

< 0.001a

0.179

0.010

0.142

 Transfusion rate (n,%)

3(16.7%)

1(5.6%)

1(5.6%)

0.414b

Secondary outcomes

 Duration of surgery (min)

137.23 ± 16.34

139.41 ± 17.55

125.83 ± 20.15

0.063a

 Hospitalization days (d)

7.74 ± 1.20

7.95 ± 1.35

7.45 ± 1.00

0.456a

 Drainage volume (mL)

446 ± 218

322 ± 185

274 ± 118

0.017a

0.074

0.006

0.360

 Maximum Hb drop(g/L)

20.22 ± 12.31

19.84 ± 10.77

17.84 ± 10.77

0.795a

Postop. Laboratory values

Hb (g/L)

 POD#1

113.17 ± 10.14

113.93 ± 9.74

115.15 ± 10.22

0.837a

 POD#3

104.16 ± 12.33

106.71 ± 11.51

113.64 ± 10.18

0.043a

0.526

0.017

0.064

Hct (%)

 POD#1

34.46 ± 3.77

34.51 ± 2.35

36.14 ± 3.26

0.207a

 POD#3

31.07 ± 5.13

31.37 ± 3.43

33.52 ± 2.87

0.135a

D-dimer (mg/L)

 POD#1

3.96 ± 1.14

4.01 ± 1.59

3.74 ± 1.33

0.820a

 POD#3

2.62 ± 0.81

2.88 ± 0.72

2.33 ± 0.60

0.116a

FDP (mg/L)

 POD#1

7.67 ± 1.21

7.51 ± 1.39

6.84 ± 0.93

0.096a

 POD#3

4.84 ± 1.16

4.64 ± 1.03

4.68 ± 0.87

0.827 a

  1. Abbreviations: ANOVA analysis of variance, POD#1 the first postoperative day, POD#3 the third postoperative day
  2. P1 represents the p value obtained by comparison between single-dose and two-dose groups
  3. P2 represents the p value obtained by comparison between single-dose and multiple-dose group
  4. P3 represents the p value obtained by comparison between two-dose and multiple-dose group
  5. Intergroup comparisons performed using ANOVA or Chi-square test (aANOVA; bChi-square test)