Cordymin alleviates osteoporosis induced by hindlimb unloading via regulating the gut - microelements -bone axis --for non-clinical studies

Table 1 Bone structural variables of the fifth lumbar vertebral body by micro-CT (Mean ± standard deviation)

Groups	Trabecular bone volume (%)	Trabecular connectivity (1/mm³)	Trabecular number (1/mm)	Trabecular thickness (µm)	Structural model index	Cortical thickness (µm)
Control group	37.0 ± 5.1	48.3 ± 11.4	3.8 ± 0.3	101.5 ± 11.1	-0.38 ± 0.2	276 ± 40
Hindlimb unloading	27.1 ± 7.0^##	39.1 ± 11.2^#	3.4 ± 0.2^#	87.0 ± 11.6^##	0.08 ± 0.4^##	249 ± 29^#
Cordymin-25	29.0 ± 8.0	38.6 ± 11.0	3.7 ± 0.7	85.0 ± 10.4	0.09 ± 0.5	248 ± 28
Cordymin-50	31.9 ± 7.0^*	38.8 ± 12.0	3.2 ± 0.5	101.1 ± 10.5^*	0.08 ± 0.4	283 ± 28
Cordymin-100	39.0 ± 3.8^**	37.6 ± 7.0	3.9 ± 0.5	121.2 ± 12.0^**	-0.54 ± 0.4	300 ± 18

The data are presented as mean ± SD (n = 10 per group). Values are mean ± SEM. n = 10. *p < 0.05, ** p < 0.01 compared to the hindlimb unloading.^# p < 0.05 compared to the control group, ^## p < 0.01 compared to the control group

ISSN: 1471-2474