Table 4 Key results of one-way sensitivity analysis
From: Cost-consequence analysis of continuous denosumab therapy for osteoporosis treatment in South Korea
Analysis | Difference (Dmab-C - Dmab-D) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Fracture risks | Mortality | Costs | ||||||||
VTa | Non-VTa | Total a | Fracture-related deathsa | Continuous treatment drugb | Subsequent treatment drugb | Total fracture treatmentb | Productivity lossb | Total lifetimeb | ||
Base-case | -34.21 | -12.43 | -46.64 | -1.29 | 717,120 | -808,651 | -1,263,124 | - | -1,354,655 | |
Discount rate | 0% | -59.48 | -21.85 | -81 | -4.04 | 754,004 | -915,760 | -2,202,517 | - | -2,364,273 |
3% | -40.23 | -14.67 | -55 | -1.83 | 728,943 | -839,036 | -1,486,710 | - | -1,596,804 | |
Time horizon | 3 years | -6.68 | -2.48 | -9.16 | -0.06 | 717,120 | -667,236 | -247,984 | - | -198,100 |
5 years | -10.80 | -3.87 | -14.67 | -0.10 | 717,120 | -718,177 | -397,194 | - | -398,251 | |
10 years | -18.77 | -6.65 | -25.42 | -0.21 | 717,120 | -762,596 | -688,520 | - | -733,996 | |
Starting age | 72.3c | -23.94 | -8.37 | -32.31 | -2.56 | 705,908 | -755,078 | -875,038 | - | -924,208 |
Offset time | 1 year | -34.23 | -12.43 | -46.66 | -1.29 | 717,120 | -812,642 | -1,263,741 | - | -1,359,263 |
3 years | -34.18 | -12.43 | -47 | -1.29 | 717,120 | -803,556 | -1,262,323 | - | -1,348,758 | |
Continuous treatment durationd | 1 year | -32.82 | -10.28 | -43 | -1.20 | 165,561 | -181,090 | -1,167,781 | - | -1,183,310 |
2 years | -33.57 | -11.44 | -45 | -1.25 | 460,590 | -516,956 | -1,219,014 | - | -1,275,380 | |
5 years | -35.24 | -14.02 | -49 | -1.36 | 1,133,895 | -1,281,661 | -1,333,693 | - | -1,481,460 | |
Lifetime | -38.05 | -18.18 | -56 | -1.67 | 2,364,007 | -2,654,788 | -1,521,662 | - | -1,812,443 | |
Continuous treatment until T-score − 1.5e | -2.5 < T-score≤-1.5 | -34.58 | -12.74 | -47.32 | -1.33 | 745,271 | -683,387 | -1,281,513 | - | -1,219,629 |
Perspective | Societal | -34.21 | -12.43 | -46.64 | -1.29 | 717,120 | -808,651 | -1,263,124 | -27,663,741 | -29,025,949 |