Opioids and fibromyalgia: frequency of use and factors associated with increased consumption in patients remitted to a tertiary care center

Table 4 Percentages of patients treated with additional drugs, and total number of drugs consumed by all groups of patients at the first visit

	ICAF cohort	SOC patients	Non-SOC patients	p^*
Analgesics	75.3	75.0	75.3	0.999
NSAIDs	46.6	41.0	47.1	0.347
Benzodiazepines	56.2	73.0	54.5	< 0.0001
Antidepressants	63.7	86.0	61.5	< 0.0001
Anticonvulsants	26.6	57.0	23.5	< 0.0001
Z-drugs	5.4	9.0	5.1	0.105
Antipsychotics	2.8	6.0	2.4	0.038
Antihistamines	5.2	10.0	4.8	0.025
Other CNS drugs	9.9	16.0	9.3	0.033
Total number of drugs^** (mean (sd))	3.7 (2.1)	4.9 (2.1)	3.6 (2.1)	< 0.0001

p^* Compares SOC vs. non-SOC groups. ^** Strong opioids are not included. SOC = strong opioid consumer sd = standard deviation. NSAIDs = non-steroidal anti-inflammatory drugs. CNS = central nervous system. ns = not significant

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